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Article

MeCP2-mediated alterations of striatal features accompany psychomotor deficits in a mouse model of Rett syndrome.

Brain structure & function - 1 Jan 2015

Kao Fang-Chi, Su San-Hua, Carlson Gregory C, Liao Wenlin

Abstract excerpt

Rett Syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the methyl-CpG-binding protein 2 (MECP2) gene. Affected individuals develop motor deficits including stereotypic hand movements, impaired motor learning and difficulties with movement. To understand the neural mechanisms of motor deficits in RTT, we characterized the molecular and cellular phenotypes in the striatum, the major input...

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Source

Identifiers

PMID: 24218106
DOI: 10.1007/s00429-013-0664-x

Genes

MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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