Article
Improvement of the Rett syndrome phenotype in a MeCP2 mouse model upon treatment with levodopa and a dopa-decarboxylase inhibitor.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2014
Szczesna Karolina, de la Caridad Olga, Petazzi Paolo, Soler Marta, Roa Laura, Saez Mauricio A, Fourcade Stéphane, Pujol Aurora, Artuch-Iriberri Rafael, Molero-Luis Marta, Vidal August, Huertas Dori, Esteller Manel
Abstract excerpt
Rett Syndrome is a neurodevelopmental autism spectrum disorder caused by mutations in the gene coding for methyl CpG-binding protein (MeCP2). The disease is characterized by abnormal motor, respiratory, cognitive impairment, and autistic-like behaviors. No effective treatment of the disorder is available. Mecp2 knockout mice have a range of physiological and neurological abnormalities that resemble the human...
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