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Article

Mirtazapine treatment in a young female mouse model of Rett syndrome identifies time windows for the rescue of early phenotypes.

Experimental neurology - 1 Jul 2022

Flores Gutiérrez Javier, Natali Giulia, Giorgi Jacopo, De Leonibus Elvira, Tongiorgi Enrico

Abstract excerpt

Rett Syndrome (RTT) is a rare X-linked neurodevelopmental disorder, mainly caused by mutations in the MECP2 gene. Reduction in monoamine levels in RTT patients and mouse models suggested the possibility to rescue clinical phenotypes through antidepressants. Accordingly, we tested mirtazapine (MTZ), a noradrenergic and specific-serotonergic tetracyclic antidepressant (NaSSA). In previous studies, we showed high...

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PMID: 35358499
DOI: 10.1016/j.expneurol.2022.114056

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