Article
Rett syndrome treatment in mouse models: searching for effective targets and strategies.
Neuropharmacology - 1 May 2013
Ricceri Laura, De Filippis Bianca, Laviola Giovanni
Abstract excerpt
Rett syndrome (RTT) is a pervasive developmental disorder, primarily affecting girls with a prevalence of 1 in every 10,000 births; it represents the second most common cause of intellectual disability in females. Mutations in the gene encoding methyl-CpG-binding protein 2 (MECP2) have been identified as clear etiological factors in more than 90% of classical RTT cases. Whereas the mechanisms leading to the...
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