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Article

A small-molecule TrkB ligand improves dendritic spine phenotypes and atypical behaviors in female Rett syndrome mice.

Disease models & mechanisms - 1 Jun 2024

Medeiros Destynie, Ayala-Baylon Karen, Egido-Betancourt Hailey, Miller Eric, Chapleau Christopher, Robinson Holly, Phillips Mary L, Yang Tao, Longo Frank M, Li Wei, Pozzo-Miller Lucas

Abstract excerpt

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in MECP2, which encodes methyl-CpG-binding protein 2, a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are lower in multiple brain regions of Mecp2-deficient mice, and experimentally increasing BDNF levels improve atypical phenotypes in Mecp2 mutant mice. Due to the low blood-brain...

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Source

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Identifiers

PMID: 38785269
DOI: 10.1242/dmm.050612
PMCID: PMC11139040

Genes

BDNF
MECP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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