Article

Mirtazapine treatment in a young female mouse model of Rett syndrome identifies time windows for the rescue of early phenotypes during development

2021-12-17

Abstract excerpt

<h4>ABSTRACT</h4> Rett Syndrome (RTT) is a rare X-linked neurodevelopmental disorder, mainly caused by mutations in the MECP2 gene. Reduction in monoamine levels in RTT patients and mouse models suggested the possibility to rescue clinical phenotypes through antidepressants. Accordingly, we tested mirtazapine (MTZ), a noradrenergic and specific-serotonergic tetracyclic antidepressant (NaSSA). In previous studies...

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Literature Corpus work: 1ce88474-1cf3-5902-8525-1cc4da1b719e
DOI: 10.1101/2021.12.17.473107

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