Article

Sex-Specific Characterization of a Novel Osteoarthritis-Induced Heart Failure Model in Mice

2025-10-16

Abstract excerpt

Chronic low-grade inflammation is increasingly recognized as a key driver of heart failure (HF) progression; however, the direct contribution of systemic inflammatory disorders such as osteoarthritis (OA) remains unclear. Here, we establish a murine model of OA-induced HF using destabilization of the medial meniscus (DMM) to induce systemic inflammation and sex-specific cardiac remodeling. Longitudinal echocardiog...

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Literature Corpus work: 5d4c572b-3e82-5468-9459-1823bd852f41
DOI: 10.1101/2025.10.16.682846

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