Article

Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male Mice

2024-04-05

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Right ventricular dysfunction (RVD) portends increased death risk for heart failure (HF) and pulmonary arterial hypertension (PAH) patients, regardless of left ventricular function or etiology. In both, RVD arises from the chronic RV pressure overload, and represents advanced cardiopulmonary disease. RV remodeling responses and survival rates of HF and PAH patients, however,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: caf004a3-5761-5ee7-8ae9-19348cd6a88c
DOI: 10.1101/2024.04.03.588013

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Extracellular Matrix Instability and Chronic Inflammation Underlie Maladaptive Right Ventricular Pressure Overload Remodeling and Failure in Male MiceDOI 10.1101/2024.04.03.588013Read

Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats.Semantic proximity Read

Untangling the mechanisms of pulmonary hypertension-induced right ventricular stiffening in a large animal modelSemantic proximity Read

Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxiaSemantic proximity Read

Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?Semantic proximity Read

Sex-Specific Characterization of a Novel Osteoarthritis-Induced Heart Failure Model in MiceSemantic proximity Read

Transcriptional profiling unveils molecular subgroups of adaptive and maladaptive right ventricular remodeling in pulmonary hypertension.Semantic proximity Read

Right ventricular phenotypic characteristics in subjects with primary pulmonary hypertension or idiopathic dilated cardiomyopathy.Semantic proximity Read

Exaggerated Right Ventricular Dysfunction in Females with Group 3 Pulmonary HypertensionSemantic proximity Read

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary AgingSemantic proximity Read

Dynamic microRNA expression during the transition from right ventricular hypertrophy to failureSemantic proximity Read

Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial HypertensionSemantic proximity Read

Right ventricular phenotype, function, and failure: a journey from evolution to clinics.Semantic proximity Read