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Article

Gene expression analysis to identify mechanisms underlying heart failure susceptibility in mice and humans.

Basic research in cardiology - 8 Jan 2018

Koentges Christoph, Pepin Mark E, Müsse Carolyn, Pfeil Katharina, Alvarez Sonia V Viteri, Hoppe Natalie, Hoffmann Michael M, Odening Katja E, Sossalla Samuel, Zirlik Andreas, Hein Lutz, Bode Christoph, Wende Adam R, Bugger Heiko

Abstract excerpt

Genetic factors are known to modulate cardiac susceptibility to ventricular hypertrophy and failure. To determine how strain influences the transcriptional response to pressure overload-induced heart failure (HF) and which of these changes accurately reflect the human disease, we analyzed the myocardial transcriptional profile of mouse strains with high (C57BL/6J) and low (129S1/SvImJ) susceptibility for HF...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Failure

Share to Hypertrophy, Left Ventricular

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Share to Ventricular Function, Left

Share to Ventricular Remodeling

Source

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Identifiers

PMID: 29288409
DOI: 10.1007/s00395-017-0666-6
PMCID: PMC5764079

Genes

FN1
LOX
NOX4
POSTN
TGFB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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