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Article

TNFR2 Agonism as a Sex-Specific Therapy for Novel Osteoarthritis-Induced Cardiac Dysfunction

2026-07-10

Abstract excerpt

Osteoarthritis (OA), a degenerative joint disease, is associated with increased systemic inflammation, chronic pain, and cardiovascular dysfunction. Epidemiological evidence establishes that OA increases the risk of cardiovascular disease (CVD) threefold, yet the causal role of OA’s contributions remains underexamined. We assessed cardiac function longitudinally following destabilization of the medial meniscus (DM...

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Literature Corpus work
a58c99e6-89c2-5d2d-9044-53a01a9f0f48
DOI
10.64898/2026.07.06.736778
Open publication

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