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Article

Age and gender effects on echocardiographic and histopathological cardiac phenotypes in healthy adult mice.

Animal models and experimental medicine - 1 Apr 2026

Wen Shuang, Shao Xijia, Zhang Xiulin, Zhang Ningning, Chen Xiao, Yue Guangxin, Song Jiangping

Abstract excerpt

BACKGROUND: Cardiac structure and function undergo progressive age-related changes influenced by sex, yet systematic characterization of these physiological variations in preclinical models remains incomplete. METHODS: Using echocardiography and histopathology, we examined age- and sex-dependent cardiac phenotypes in healthy adult C57BL/6J mice (n = 40), stratified into eight groups by age (8, 12, 20, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41873615
DOI: 10.1002/ame2.70183
PMCID: PMC13242733

Genes

ATP2B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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