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Dysregulated expression of <i>Hoxa1</i> isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromes

2023-04-24

Abstract excerpt

The homeobox gene, Hoxa1 , has two different isoforms generated by alternative splicing: a full-length homeodomain-containing Hoxa1 ( Hoxa1-FL ), and a truncated Hoxa1 ( Hoxa1-T ), that lacks the homeodomain. The effects of the distinct Hoxa1 isoforms in hematopoiesis have not been investigated. Oncoretroviral studies revealed that Hoxa1-T acts in a dominant negative manner, regulating transcriptionally acti...

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Literature Corpus work
f65f5801-f8af-5e89-a10c-be37f6b5cb60
DOI
10.1101/2023.04.24.538176
Open publication

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Dysregulated expression of <i>Hoxa1</i> isoforms in hematopoietic stem and progenitor cells causes myelodysplastic syndromesDOI 10.1101/2023.04.24.538176
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