Article
Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice.
Cell reports - 31 Aug 2021
Kim Sanghyun P, Srivatsan Sridhar N, Chavez Monique, Shirai Cara L, White Brian S, Ahmed Tanzir, Alberti Michael O, Shao Jin, Nunley Ryan, White Lynn S, Bednarski Jeff, Pehrson John R, Walter Matthew J
Abstract excerpt
Somatic mutations in spliceosome genes are found in ∼50% of patients with myelodysplastic syndromes (MDS), a myeloid malignancy associated with low blood counts. Expression of the mutant splicing factor U2AF1(S34F) alters hematopoiesis and mRNA splicing in mice. Our understanding of the functionally relevant alternatively spliced target genes that cause hematopoietic phenotypes in vivo remains incomplete. Here,...
Topics
- Alternative Splicing
- Animals
- B-Lymphocytes
- Binding Sites
- Case-Control Studies
- HEK293 Cells
- Histones
- Humans
- K562 Cells
- Lymphopoiesis
- Mice, 129 Strain