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Article

U2af1 is required for survival and function of hematopoietic stem/progenitor cells.

Leukemia - 1 Aug 2021

Dutta Avik, Yang Yue, Le Bao T, Zhang Yifan, Abdel-Wahab Omar, Zang Chongzhi, Mohi Golam

Abstract excerpt

U2AF1 is involved in the recognition of the 3' splice site during pre-mRNA splicing. Mutations in U2AF1 are frequently observed in myelodysplastic syndromes. However, the role of wild-type U2AF1 in normal hematopoiesis has remained elusive. Using a novel conditional U2af1 knockout allele, we have found that deletion of U2af1 results in profound defects in hematopoiesis characterized by pancytopenia, ablation of...

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Identifiers

PMID: 33414485
DOI: 10.1038/s41375-020-01116-x
PMCID: PMC8283943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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