Article

Srsf2 P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia like disease in mice

2022-06-21

Abstract excerpt

Recurrent mutations in two pathways - the RNA spliceosome (eg. SRSF2, SF3B1, U2AF1 ) and epigenetic regulators (eg. DNMT3, TET2 ) – contribute to the development of myelodysplastic syndrome (MDS) and related myeloid neoplasms. In chronic myelomonocytic leukemia (CMML), SRSF2 mutations occur in ∼50% of patients and TET2 mutations in ∼60%, representing two of the most frequent mutations in these cancers. Clonal...

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Literature Corpus work: e07837c6-8910-54f2-9abe-780e82d4f4d6
DOI: 10.1101/2022.06.21.496931

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Srsf2 P95H/+ co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia like disease in miceDOI 10.1101/2022.06.21.496931Read

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<i> Srsf2 <sup>P95H/+</sup> </i> co-operates with loss of TET2 to promote myeloid bias and initiate a chronic myelomonocytic leukemia like disease in mice

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