Article

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

2020-08-03

Abstract excerpt

We used two approaches to design proteins with shape and chemical complementarity to the receptor binding domain (RBD) of SARS-CoV-2 Spike protein near the binding site for the human ACE2 receptor. Scaffolds were built around an ACE2 helix that interacts with the RBD, or de novo designed scaffolds were docked against the RBD to identify new binding modes. In both cases, designed sequences were optimized first in s...

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Literature Corpus work: 5cb0a74d-2a18-579c-8d08-26d18c19e6e4
DOI: 10.1101/2020.08.03.234914

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