Article
Engineered ACE2 receptor traps potently neutralize SARS-CoV-2.
Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 2020
Glasgow Anum, Glasgow Jeff, Limonta Daniel, Solomon Paige, Lui Irene, Zhang Yang, Nix Matthew A, Rettko Nicholas J, Zha Shoshana, Yamin Rachel, Kao Kevin, Rosenberg Oren S, Ravetch Jeffrey V, Wiita Arun P, Leung Kevin K, Lim Shion A, Zhou Xin X, Hobman Tom C, Kortemme Tanja, Wells James A
Abstract excerpt
An essential mechanism for severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection begins with the viral spike protein binding to the human receptor protein angiotensin-converting enzyme II (ACE2). Here, we describe a stepwise engineering approach to generate a set of affinity optimized, enzymatically inactivated ACE2 variants that...
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