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Article

In silico design of miniprotein to inhibit SARS-CoV-2 variant Omicron spike protein.

Physical chemistry chemical physics : PCCP - 31 May 2023

Wu Jianhua, Zhang Hong-Xing, Zhang Jilong

Abstract excerpt

Omicron is a novel variant of SARS-CoV-2 that is currently spreading globally as the dominant strain. The virus first enters the host cell through the receptor binding domain (RBD) of the spike protein by interacting with the angiotensin-converting enzyme 2 (ACE2). Thus, the RBD protein is an ideal target for the design of drugs against the Omicron variant. Here, we designed several miniprotein inhibitors in...

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PMID: 37199217
DOI: 10.1039/d3cp01167d

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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