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Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2

4 Nov 2020

Abstract excerpt

Abstract The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19. However, traditional antibody production is hampered by long development times and costly production. Here, we report the rapid isolation and characterization of nanobodies from a synthetic library, known as sybodies (Sb), that...

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PMID: 33149112
DOI: 10.1038/s41467-020-19204-y

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