Article

Broad-Spectrum Coronavirus Inhibitors Discovered by Modeling Viral Fusion Dynamics

2024-03-29

Abstract excerpt

Broad-spectrum therapeutics capable of inhibiting SARS-CoV-2, its variants, and related coronaviruses hold promise in curbing the spread of COVID-19 and averting future pandemics. Here, we employed a multidisciplinary approach that included molecular dynamics simulation (MDS) and artificial intelligence (AI)-based docking predictions to identify potent inhibitors that target a conserved region within the SARS-CoV-...

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Literature Corpus work: d5233d73-8bad-54c4-aff9-198fe46f6b05
DOI: 10.1101/2024.03.28.587229

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