Article

Multivalent designed proteins protect against SARS-CoV-2 variants of concern

2021-07-07

Abstract excerpt

Escape variants of SARS-CoV-2 are threatening to prolong the COVID-19 pandemic. To address this challenge, we developed multivalent protein-based minibinders as potential prophylactic and therapeutic agents. Homotrimers of single minibinders and fusions of three distinct minibinders were designed to geometrically match the SARS-CoV-2 spike (S) trimer architecture and were optimized by cell-free expression and foun...

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Literature Corpus work: 2c3264d4-6a24-5eda-a08e-ea70f9334eb4
DOI: 10.1101/2021.07.07.451375

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