Article

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor traps

2022-08-10

Abstract excerpt

<h4>Summary</h4> The SARS-CoV-2 Omicron variant, with 15 mutations in Spike receptor binding domain (Spike-RBD), renders virtually all clinical monoclonal antibodies against WT SARS-CoV-2 ineffective. We recently engineered the SARS-CoV-2 host entry receptor, ACE2, to tightly bind WT-Spike-RBD and prevent viral entry into host cells (“receptor traps”). Here we determine cryo-EM structures of our receptor traps in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2eedd01-5602-5e91-9eec-cd2d3029cf19
DOI: 10.1101/2022.08.09.503400

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational pipeline provides mechanistic understanding of Omicron variant of concern neutralizing engineered ACE2 receptor trapsDOI 10.1101/2022.08.09.503400Read

Structures of Omicron spike complexes and implications for neutralizing antibody developmentSemantic proximity Read

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discoverySemantic proximity Read

Structural and functional characterizations of altered infectivity and immune evasion of SARS-CoV-2 Omicron variantSemantic proximity Read

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.Semantic proximity Read

Omicron SARS-CoV-2 mutations stabilize spike up-RBD conformation and lead to a non-RBM-binding monoclonal antibody escape.Semantic proximity Read

Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagementSemantic proximity Read

Improved binding affinity of the Omicron’s spike protein with hACE2 receptor is the key factor behind its increased virulenceSemantic proximity Read

SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein-ACE2 complex.Semantic proximity Read

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM.Semantic proximity Read

Characterization of SARS-CoV-2 Omicron spike RBD reveals significantly decreased stability, severe evasion of neutralizing-antibody recognition but unaffected engagement by decoy ACE2 modified for enhanced RBD bindingSemantic proximity Read

Structural insights into the SARS-CoV-2 Omicron RBD-ACE2 interactionSemantic proximity Read