Article

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

2020-08-01

Abstract excerpt

An essential mechanism for SARS-CoV-1 and -2 infection begins with the viral spike protein binding to the human receptor protein angiotensin-converting enzyme II (ACE2). Here we describe a stepwise engineering approach to generate a set of affinity optimized, enzymatically inactivated ACE2 variants that potently block SARS-CoV-2 infection of cells. These optimized receptor traps tightly bind the receptor binding d...

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Literature Corpus work: 26328b82-47f7-5104-ad82-220a85f65175
DOI: 10.1101/2020.07.31.231746

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