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A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike

10 Aug 2022

Abstract excerpt

Neutralizing antibodies targeting the SARS-CoV-2 spike protein have shown a great preventative/therapeutic potential. Here, we report a rapid and efficient strategy for the development and design of SARS-CoV-2 neutralizing humanized nanobody constructs with sub-nanomolar affinities and nanomolar potencies. CryoEM-based structural analysis of the nanobodies in complex with spike revealed two distinct binding...

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PMID: 35947606
DOI: 10.1371/journal.pone.0272364

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