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Article

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

12 Apr 2022

Abstract excerpt

New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple computationally designed miniprotein inhibitors of SARS-CoV-2. We found the broadest efficacy was achieved with a homotrimeric version of the...

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PMID: 35412328
DOI: 10.1126/scitranslmed.abn1252

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