Article

Beyond gene length: Exon-intron architecture and isoform potential in the evolution of eukaryotic complexity

2026-03-27

Abstract excerpt

Alternative splicing is a major source of human transcriptomic and phenotypic variation, yet its evolutionary contribution to genomic complexity remains unresolved. It has been shown that a mean gene length can be the most basic but remarkably efficient proxy for multicellular genome complexity, whereas mean protein length is not, as it plateaus abruptly early in eukaryotic evolution. Here, we show that, across 2,...

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Identifiers and source

Literature Corpus work: 0074137d-4503-51dc-a3ed-4c01ad56d352
DOI: 10.64898/2026.03.25.714307

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