Article

Population-scale interpretation of RNA isoform diversity enabled by Isopedia

2026-03-25

Abstract excerpt

Alternative splicing generates extensive transcriptomic complexity, yet “novelty” is often inflated because of incomplete reference annotations, with 20-70% of transcripts in RNA-Seq studies labeled as novel. Isopedia provides an expandable data structure for reference-agnostic isoform annotation, which we demonstrate here through a population-scale catalog of 1,007 long-read datasets spanning 37 diverse biologica...

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Literature Corpus work: dc322311-9611-50ce-af82-d383e4e399a0
DOI: 10.64898/2026.03.23.713667

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