Article

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models

2021-12-13

Abstract excerpt

Models of MECP2 dysfunction in Rett syndrome (RTT) assume that transcription rate changes directly correlate with altered steady-state mRNA levels. However, limited evidence suggests that transcription rate changes are buffered by poorly understood compensatory post-transcriptional mechanisms. Here we measure transcription rate and mRNA half-life changes in RTT patient neurons using RATE-seq, and reinterpret nucle...

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Literature Corpus work: 5c9b0d19-0203-52a5-a0a3-6a6f62ec150e
DOI: 10.1101/2021.12.11.472181

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