Article
DNA methylation in the gene body influences MeCP2-mediated gene repression.
Proceedings of the National Academy of Sciences of the United States of America - 27 Dec 2016
Kinde Benyam, Wu Dennis Y, Greenberg Michael E, Gabel Harrison W
Abstract excerpt
Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the methyl-CpG binding protein gene (MECP2). MeCP2 is a methyl-cytosine binding protein that is proposed to function as a transcriptional repressor. However, multiple gene expression studies comparing wild-type and MeCP2-deficient neurons have failed to identify gene expression changes consistent with loss of a classical transcriptional...
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