Article

mRNA stability fine tunes gene expression in the developing cortex to control neurogenesis

2024-07-22

Abstract excerpt

RNA expression levels are controlled by the complementary processes of synthesis and degradation. Although mis-regulation of RNA turnover is linked to neurodevelopmental disorders, how it contributes to cortical development is largely unknown. Here, we profile the RNA stability landscape of the cortex across development and demonstrate that control of stability by the CCR4-NOT complex is essential for corticogenes...

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Literature Corpus work: 9a8b5635-f58d-5f97-b0e9-f984574d6d24
DOI: 10.1101/2024.07.22.604643

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