Article
Biotin tagging of MeCP2 in mice reveals contextual insights into the Rett syndrome transcriptome.
Nature medicine - 1 Oct 2017
Johnson Brian S, Zhao Ying-Tao, Fasolino Maria, Lamonica Janine M, Kim Yoon Jung, Georgakilas George, Wood Kathleen H, Bu Daniel, Cui Yue, Goffin Darren, Vahedi Golnaz, Kim Tae Hoon, Zhou Zhaolan
Abstract excerpt
Mutations in MECP2 cause Rett syndrome (RTT), an X-linked neurological disorder characterized by regressive loss of neurodevelopmental milestones and acquired psychomotor deficits. However, the cellular heterogeneity of the brain impedes an understanding of how MECP2 mutations contribute to RTT. Here we developed a Cre-inducible method for cell-type-specific biotin tagging of MeCP2 in mice. Combining this...
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