Article

Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain

2026-01-29

Abstract excerpt

Spatial and activity-dependent gene regulation in the mammalian brain requires coordinated control of RNA synthesis and degradation 1,2 , yet spatially resolved measurement of RNA turnover kinetics in complex tissues remains technically challenging 3 . Here, we present spatial NT-seq , an approach that integrates transgenesis-free metabolic RNA labeling with in situ chemical recoding to spatially co-map RNA ab...

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Literature Corpus work: 5e34ef01-4ac0-54e2-adee-a95f88c9224c
DOI: 10.64898/2026.01.29.702431

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