Article

Bias toward long gene misregulation in synaptic disorders can be an artefact of amplification-based methods

2017-12-29

Abstract excerpt

<h4>SUMMARY</h4> Several recent studies have suggested that genes that are longer than 100 kilobases are more likely to be misregulated in neurological diseases associated with synaptic dysfunction, such as autism and Rett syndrome. These length-dependent transcriptional changes are modest in Mecp2 -mutant samples, but, given the low sensitivity of high-throughput transcriptome profiling technology, the statisti...

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Literature Corpus work: bc4ec587-e7ce-5a33-a706-a9ebe9f5fc7b
DOI: 10.1101/240705

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