Article

Transcriptional boosting and buffering during neurodevelopment by shifts in mRNA instability

2023-03-01

Abstract excerpt

<h4>ABSTRACT</h4> The contribution of mRNA half-life is commonly overlooked when examining changes in mRNA abundance during development. mRNA levels are regulated by transcription rate or mRNA half-life, but combinations of both could boost or buffer the final steady-state. We measured transcription rate and mRNA half-life changes during human induced pluripotent stem cell (iPSC)-derived neuronal development usin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9c51d42-44ca-58c1-bdb2-efde9bb34ec0
DOI: 10.1101/2023.03.01.530249

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional boosting and buffering during neurodevelopment by shifts in mRNA instabilityDOI 10.1101/2023.03.01.530249Read

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome modelsSemantic proximity Read

The genetic and biochemical determinants of mRNA degradation rates in mammalsSemantic proximity Read

mRNA stability fine tunes gene expression in the developing cortex to control neurogenesisSemantic proximity Read

Genome-wide RNA structure changes during human neurogenesis drive gene regulatory networksSemantic proximity Read

Comprehensive annotation of 3′UTRs from primary cells and their quantification from scRNA-seq dataSemantic proximity Read

Absolute Scaling of Single-Cell Transcriptomes Reveals Pervasive Hypertranscription in Adult Stem and Progenitor CellsSemantic proximity Read

Dynamic changes in mRNA isoform usage during human retinal organoid developmentSemantic proximity Read

RNADecayCafe, a uniformly processed atlas of RNA half-life estimates across multiple human cell linesSemantic proximity Read

Widespread translational remodeling during human neuronal differentiationSemantic proximity Read

Expansion of RNA sequence diversity and RNA editing rates throughout human cortical developmentSemantic proximity Read

A spatiotemporally resolved atlas of mRNA decay in the <i>C. elegans</i> embryo reveals differential regulation of mRNA stability across stages and cell typesSemantic proximity Read

Stereoscopic RNA Analysis of Transcriptional and Post-transcriptional RegulationSemantic proximity Read