Article

SARM1 deficiency, which prevents Wallerian degeneration, upregulates XAF1 and accelerates prion disease

2018-12-03

Abstract excerpt

SARM1 (sterile α and HEAT/armadillo motifs containing protein) is a member of the MyD88 (myeloid differentiation primary response gene 88) family which mediates innate immune responses. Because inactivation of SARM1 prevents various forms of axonal degeneration, we tested whether it might protect against prion-induced neurotoxicity. Instead, we found that SARM1 deficiency exacerbates the progression of prion patho...

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Literature Corpus work: 5c7a7f18-f788-5d6f-b54d-cdf7a75e908f
DOI: 10.1101/485052

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