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Article

Passenger Mutations Confound Phenotypes of SARM1-Deficient Mice.

Cell reports - 7 Apr 2020

Uccellini Melissa B, Bardina Susana V, Sánchez-Aparicio Maria Teresa, White Kris M, Hou Ying-Ju, Lim Jean K, García-Sastre Adolfo

Abstract excerpt

The Toll/IL-1R-domain-containing adaptor protein SARM1 is expressed primarily in the brain, where it mediates axonal degeneration. Roles for SARM1 in TLR signaling, viral infection, inflammasome activation, and chemokine and Xaf1 expression have also been described. Much of the evidence for SARM1 function relies on SARM1-deficient mice generated in 129 ESCs and backcrossed to B6. The Sarm1 gene lies in a...

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Identifiers

PMID: 32268088
DOI: 10.1016/j.celrep.2020.03.062
PMCID: PMC7226674

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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