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Article

Multiple domain interfaces mediate SARM1 autoinhibition.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2021

Shen Chen, Vohra Mihir, Zhang Pengfei, Mao Xianrong, Figley Matthew D, Zhu Jian, Sasaki Yo, Wu Hao, DiAntonio Aaron, Milbrandt Jeffrey

Abstract excerpt

Axon degeneration is an active program of self-destruction mediated by the protein SARM1. In healthy neurons, SARM1 is autoinhibited and, upon injury autoinhibition is relieved, activating the SARM1 enzyme to deplete NAD+ and induce axon degeneration. SARM1 forms a homomultimeric octamer with each monomer composed of an N-terminal autoinhibitory ARM domain, tandem SAM domains that mediate multimerization, and a...

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Identifiers

PMID: 33468661
DOI: 10.1073/pnas.2023151118
PMCID: PMC7848697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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