Article

Loss of Sarm1 non-autonomously protects Schwann cells from chemotoxicity

2018-12-11

Abstract excerpt

<h4>ABSTRACT</h4> The obligate pro-degenerative protein Sarm1 is essential for Wallerian axon degeneration. Inhibition of Sarm1 has been proposed as a promising neuroprotective strategy with clinical relevance. Yet, the conditions that will most benefit from inhibiting Sarm1 remain undefined. Here we use genetics and pharmacology in zebrafish to show that systemic elimination of Sarm1 is glioprotective. Loss of S...

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Literature Corpus work: a813dbfc-1222-572d-83ca-8b287436734e
DOI: 10.1101/493163

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