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Article

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Summers Daniel W, Gibson Daniel A, DiAntonio Aaron, Milbrandt Jeffrey

Abstract excerpt

Axon injury in response to trauma or disease stimulates a self-destruction program that promotes the localized clearance of damaged axon segments. Sterile alpha and Toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) is an evolutionarily conserved executioner of this degeneration cascade, also known as Wallerian degeneration; however, the mechanism of SARM1-dependent neuronal destruction is still...

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Identifiers

PMID: 27671644
DOI: 10.1073/pnas.1601506113
PMCID: PMC5068253

Genes

SARM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.PMID 27671644Read ↗

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