Article
Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis.
Frontiers in immunology - 1 Jan 2021
Ma Chao, Hunt Jerry B, Kovalenko Andrii, Liang Huimin, Selenica Maj-Linda B, Orr Michael B, Zhang Bei, Gensel John C, Feola David J, Gordon Marcia N, Morgan Dave, Bickford Paula C, Lee Daniel C
Abstract excerpt
Brain myeloid cells, include infiltrating macrophages and resident microglia, play an essential role in responding to and inducing neurodegenerative diseases, such as Alzheimer's disease (AD). Genome-wide association studies (GWAS) implicate many AD casual and risk genes enriched in brain myeloid cells. Coordinated arginine metabolism through arginase 1 (Arg1) is critical for brain myeloid cells to perform...
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