Article

NAD+ hydrolase Sarm1 is a key driver of synapse degeneration and memory loss in Alzheimer’s disease

2025-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Synapse degeneration is a hallmark of neurodegenerative diseases 1–3 , including Parkinson’s and Alzheimer’s disease (AD). Synapse loss has been known for decades as the strongest correlate with cognition and disease progression in AD patients 4–8 , but the molecular mechanisms that drive synapse degeneration remain elusive. Here, we identify Sarm1, a new class of NAD+ hydrolase required for W...

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Literature Corpus work: 6d6678da-bd77-518c-98f2-8a9eef9ba863
DOI: 10.64898/2025.12.21.695860

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