Article
dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.
Science (New York, N.Y.) - 27 Jul 2012
Osterloh Jeannette M, Yang Jing, Rooney Timothy M, Fox A Nicole, Adalbert Robert, Powell Eric H, Sheehan Amy E, Avery Michelle A, Hackett Rachel, Logan Mary A, MacDonald Jennifer M, Ziegenfuss Jennifer S, Milde Stefan, Hou Ying-Ju, Nathan Carl, Ding Aihao, Brown Robert H, Conforti Laura, Coleman Michael, Tessier-Lavigne Marc, Züchner Stephan, Freeman Marc R
Abstract excerpt
Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an active autodestruction program, akin to apoptotic cell death; however, loss-of-function mutations capable of potently blocking axon self-destruction have not been described. Here, we show that loss of the Drosophila Toll receptor adaptor...
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