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Article

Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain.

Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013

Cao Yang, Chtarbanova Stanislava, Petersen Andrew J, Ganetzky Barry

Abstract excerpt

A growing body of evidence in humans implicates chronic activation of the innate immune response in the brain as a major cause of neuropathology in various neurodegenerative conditions, although the mechanisms remain unclear. In an unbiased genetic screen for mutants exhibiting neurodegeneration in Drosophila, we have recovered a mutation of dnr1 (defense repressor 1), a negative regulator of the Imd (immune...

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Identifiers

PMID: 23613578
DOI: 10.1073/pnas.1306220110
PMCID: PMC3651420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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