Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

14 Jul 2018

Abstract excerpt

Axon degeneration occurs in all neurodegenerative diseases, but the molecular pathways regulating axon destruction during neurodegeneration are poorly understood. Sterile Alpha and TIR Motif Containing 1 (Sarm1) is an essential component of the prodegenerative pathway driving axon degeneration after axotomy and represents an appealing target for therapeutic intervention in neurological conditions involving axon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Nerve injury and regeneration
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30010873
DOI: 10.1093/hmg/ddy260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosisPMID 30010873Read ↗

dSarm/Sarm1 is required for activation of an injury-induced axon death pathway.Semantic proximity Read ↗

Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease.Semantic proximity Read ↗

Gene therapy targeting SARM1 blocks pathological axon degeneration in miceSemantic proximity Read ↗

Exploring SARM1 as a target to delay programmed axon degenerationSemantic proximity Read ↗

Genetic Ablation of Sarm1 Mitigates Disease Acceleration after Traumatic Brain Injury in the SOD1G93A Transgenic Mouse Model of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

SARM1 knockout does not rescue neuromuscular phenotypes in a Charcot-Marie-Tooth disease Type 1A mouse model.Semantic proximity Read ↗

Systemic loss of Sarm1 protects Schwann cells from chemotoxicity by delaying axon degeneration.Semantic proximity Read ↗

Loss of Sarm1 non-autonomously protects Schwann cells from chemotoxicitySemantic proximity Read ↗

Targeting SARM1 improves autophagic stress-induced axonal neuropathySemantic proximity Read ↗

A Novel NAD Signaling Mechanism in Axon Degeneration and its Relationship to Innate ImmunitySemantic proximity Read ↗

Axon pathology in neurological disease: a neglected therapeutic target.Semantic proximity Read ↗

SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.