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Article

APOE4 Alters Early Transcriptional Programs and Inflammatory Signaling in Human Induced Pluripotent Stem Cells.

International journal of molecular sciences - 12 May 2026

Schulten Wiebke, Czaniera Nele Johanne, Fazel Mehran, Kaltschmidt Barbara, Kaltschmidt Christian

Abstract excerpt

The APOE4 allele represents the strongest genetic risk factor for late-onset Alzheimer's disease (AD), yet its influence on early cellular programs remains poorly understood. In this study, we investigated transcriptional differences between human induced pluripotent stem cells (iPSCs) carrying the APOE3 or APOE4 genotype. RNA sequencing revealed pronounced genotype-dependent transcriptional changes, with...

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Identifiers

PMID: 42196306
DOI: 10.3390/ijms27104325
PMCID: PMC13207287

Genes

APOE
SOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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