Article

Mechanistic modelling and Bayesian inference elucidates the variable dynamics of double-strand break repair

2015-09-04

Abstract excerpt

DNA double-strand breaks are lesions that form during metabolism, DNA replication and exposure to mutagens. When a double-strand break occurs one of a number of repair mechanisms is recruited, all of which have differing propensities for mutational events. Despite DNA repair being of crucial importance, the relative contribution of these mechanisms and their regulatory interactions remain to be fully elucidated. U...

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Literature Corpus work: 5c1f9d89-1b87-5e42-bda1-c7b03b34b3f6
DOI: 10.1101/026070

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