Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer.

Proceedings of the National Academy of Sciences of the United States of America - 28 Oct 2003

Vilenchik Michael M, Knudson Alfred G

Abstract excerpt

This article extends our previous quantitative analysis of the relationship between the dynamics of the primary structure of DNA and mutagenesis associated with single-strand lesions to an analysis of the production and processing of endogenous double-strand breaks (EDSBs) and to their implications for oncogenesis. We estimate that in normal human cells approximately 1% of single-strand lesions are converted to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Gamma Rays

Share to Incidence

Share to Models, Animal

Share to Oncogenes

Share to Xenopus laevis

Source

Open in PubMed Open full text

Identifiers

PMID: 14566050
DOI: 10.1073/pnas.2135498100
PMCID: PMC240711

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer.PMID 14566050Read ↗

What Does the History of Research on the Repair of DNA Double-Strand Breaks Tell Us?—A Comprehensive Review of Human RadiosensitivitySemantic proximity Read ↗

Endogenous base damage as a driver of genomic instability in homologous recombination-deficient cancersSemantic proximity Read ↗

Evaluating intrinsic and non-intrinsic cancer risk factorsSemantic proximity Read ↗

Mismatch repair, somatic mutations, and the origins of cancer.Semantic proximity Read ↗

The Breakome of <i>BRCA1</i> and <i>BRCA2</i> Pathway Mutation Carriers Reveals Early Processes in Breast OncogenesisSemantic proximity Read ↗

Evasion of Early Cellular Response Mechanisms following Low Level Radiation-induced DNA DamageSemantic proximity Read ↗

Cellular survival over genomic perfectionSemantic proximity Read ↗

Mechanisms of spontaneous human cancers.Semantic proximity Read ↗

DNA replication fidelity and cancer.Semantic proximity Read ↗

Sensing and repairing DNA double-strand breaks.Semantic proximity Read ↗

DNA Repair: a Double-Edged SwordSemantic proximity Read ↗

Repair of DNA double-strand breaks after low radiation doses in childhood cancer survivors and matched cancer-free individualsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.