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Article

Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage.

Scientific reports - 14 Sept 2016

McMahon Stephen J, Schuemann Jan, Paganetti Harald, Prise Kevin M

Abstract excerpt

Characterising and predicting the effects of ionising radiation on cells remains challenging, with the lack of robust models of the underlying mechanism of radiation responses providing a significant limitation to the development of personalised radiotherapy. In this paper we present a mechanistic model of cellular response to radiation that incorporates the kinetics of different DNA repair processes, the spatial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27624453
DOI: 10.1038/srep33290
PMCID: PMC5022028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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