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Article

Sensing and repairing DNA double-strand breaks.

Carcinogenesis - 1 May 2002

Jackson Stephen P

Abstract excerpt

The DNA double-strand break (DSB) is the principle cytotoxic lesion for ionizing radiation and radio-mimetic chemicals but can also be caused by mechanical stress on chromosomes or when a replicative DNA polymerase encounters a DNA single-strand break or other type of DNA lesion. DSBs also occur as intermediates in various biological events, such as V(D)J recombination in developing lymphoid cells. Inaccurate...

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PMID: 12016139
DOI: 10.1093/carcin/23.5.687

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