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New Tools to Study DNA Double-Strand Break Repair Pathway Choice

14 Oct 2013

Abstract excerpt

A broken DNA molecule is difficult to repair, highly mutagenic, and extremely cytotoxic. Such breaks can be repaired by homology-independent or homology-directed mechanisms. Little is known about the network that controls the repair pathway choice except that a licensing step for homology-mediated repair exists, called DNA-end resection. The choice between these two repair pathways is a key event for genomic...

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PMID: 24155929
DOI: 10.1371/journal.pone.0077206

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